Production and characterization of a murine/human chimeric anti-idiotype antibody that mimics ganglioside.
نویسندگان
چکیده
The VL and VH from a murine anti-idiotypic antibody that mimics ganglioside have been cloned, sequenced, and expressed as a chimeric mouse/human IgG1 antibody. The chimeric antibody retained a binding specificity indistinguishable from the original murine antibody. The VH was a member of Vgam 3.8 family. The sequences are discussed in terms of ways in which proteins may mimic ganglioside epitopes.
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ورودعنوان ژورنال:
- Cancer research
دوره 52 7 شماره
صفحات -
تاریخ انتشار 1992